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What is the endocannabinoid system?

Cannabinoids, extracted from the cannabis plant (hemp, in the case of legal CBD), are chemicals that trigger the natural cannabinoid receptors in the brain and body. Located all over the body, they are known as CB1 and CB2 receptors, and are part of the body’s endocannabinoid system. This system is extremely critical to our body’s ability to maintain homeostasis (the equilibrium of conditions for optimal functioning of various systems in the body). 

CB1 receptors are primarily found in the brain and central nervous system, and to a lesser extent in other tissues. CB1 receptors affect:

  • Motor activity
  • Thinking
  • Motor coordination
  • Appetite
  • Short-term memory
  • Pain perception
  • Immune cells

    CB2 receptors are located mostly in the peripheral organs, especially those associated with the immune system. CB2 receptors affect:

    CB1 and CB2 receptors in human body
    • Gut
    • Kidneys
    • Pancreas
    • Adipose tissue
    • Skeletal muscle
    • Bone
    • Eyes
    • Reproductive system
    • Immune system
    • Respiratory tract
    • Skin
    • Cardiovascular system
    • Liver

    Questions About CBD

    What is CBD?

    CBD is an abbreviation for cannabidiol, a phyto-cannabinoid compound
    within the category of cannabinoids, active components of cannabis.
    Unlike THC (the cannabinoid compound that produces a “high” in the
    user), hemp-derived CBD is notable for its lack of psychoactive
    properties. What CBD does possess, however, is the reported ability to
    positively affect certain functions in the human body. These reported
    effects allow CBD’s potential health benefits to be accessed by more
    people in a wider variety of circumstances.

    Is CBD legal?

    According to the Federal Farm Act of 2014, and as expanded upon with the
    Agricultural Improvement Act of 2018 (i.e., the “2018 Farm Bill”), hemp
    plants containing less than 0.3% THC are considered legal for
    cultivation and production. Wellphora CBD hemp oil is extracted from
    plants that meet those guidelines and, subject to state mandated
    limitations, is federally legal in all 50 US states.

    What's the difference between CBD and Hemp Oil?

    “Hemp Oil” is often used synonymously with “CBD Oil” in the hemp industry. Hemp seed
    oil, which contains no CBD, is also sometimes referred to by the name Hemp Oil, and can cause questions to be raised on how a product is being marketed and the CBD content of a product.

    This confusion can be a way to mislead the uneducated consumer. In fact, products labeled as hemp oil may not contain any CBD at all. It’s important to look for products with clear labels showing the overall quantity of CBD—and the mg per dose—as well as other ingredients. In a study of CBD products from 2017, almost 70% of the analyzed samples were mislabeled.

    Prior to the 2018 Farm Bill being signed by President Trump in December 2018, CBD was treated as a Schedule I controlled substance, and considered federally illegal. It was, however, already legal in 46 states at that time. Because of the federal limitations on CBD, large retailers such as Amazon, EBay, etc. did not allow CBD products to be sold on their platforms. In order for a product to be considered “federally legal,” it was labeled as “Hemp Oil,” while CBD was called “Hemp Extract”. This allowed manufacturers to ship and distribute to states where CBD was legal, prior to December 2018.

    Will Wellphora CBD make me "High"?

    No. When hemp-derived CBD is extracted from the hemp plant, the psychoactive component in hemp, THC, is present in such low, federally mandated trace amounts that it causes no “high” effect.

    Can Wellphora CBD Cause me fail a drug test?

    The THC concentration of all Wellphora products remains below the legal limit set forth by Federal regulations. This low level of THC is typically too low to be measurable during drug testing, but is still present and comes with a theoretical risk of a positive test. Legally, any positive THC test result with a hemp-derived CBD product at or below 0.3% THC would constitute a false positive. However, an employer, at their sole discretion has the right to enact a zero tolerance drug testing policy where even a false positive THC drug test could cause an issue.

    How does Wellphora use organic MCT oil?

    Our Canneuro hemp oil uses an extremely high-grade organic, fractionated coconut oil as a carrier. “Fractionated” refers to the process of separating out certain parts of regular coconut oil, to produce a healthy oil that acts as an excellent source of medium-chain triglycerides (MCT) and stays liquid at lower temperatures. MCTs can play a role in helping burn more fat and calories and reportedly may aid in weight loss. Our pure organic MCT oil is more expensive than other ingredients commonly used as a carrier for other hemp-derived CBD oils.

    What is meant by "full-spectrum" CBD?

    Hemp-derived, full-spectrum CBD contains other naturally-occurring complimentary cannabinoids, as opposed to “CBD isolate or Pure CBD,” which has had those additional components distilled out. Full-spectrum CBD is considered to be more effective than other types of CBD. This is believed to be due to the “entourage effect,” or the combined effect of multiple cannabinoids working together, naturally, within the body in ways that are still not fully
    understood or explained by science.

    Can there be any side effects from using hemp oil/CBD?

    There are currently very few (if any) negative side effects associated with CBD. CBD is generally considered safe for human and animal consumption. If someone were to take an excessive amount of CBD, you may experience effects of drowsiness. Something to consider is that CBD can help other medications work more efficiently, therefore increasing the risks of side effects from other medications. CBD can also counteract the psychoactive effects of THC at high doses.

    How many milligrams (mg) are in a Canneuro 1000 does?

    Our Canneuro 1000 is 1000mg of full-spectrum, hemp-derived CBD in a bottle that contains 30 mL of total product. Each bottle in the Canneuro line-up is designed to provide 60 doses via a 1mL dropper. Each dose is a half dropper and each half dropper is 1/2 mL. The Canneuro 1000 would contain approximately 17mg of CBD per dose, which is recommended 2-3x daily.

    How long is one serving effective?

    The optimum serving of CBD is completely dependent on the person. There are several factors that play a key role on how long you may feel the effects from a single serving. As a general guideline we recommend 2-3x daily—but metabolism, body mass, activity level, and severity of symptoms all play a factor and these can change daily.

    For example, one of our team notices relief during the height of allergy season by using an additional serving around 2-3 PM, in addition to taking it morning and night. An extra serving after an extended workout can also be effective.

    How many milligrams (mg) of CBD should I take?

    Adult servings can range anywhere from 30mg-300mg as a daily amount. The total number of milligrams/day is often broken up as more than one serving, to be split up throughout the day. We recommend that each person needs to find their own “sweet spot” when it comes to servings, for his or her own particular needs.

    About hemp-derived CBD servings

    Note: CBD is a product of nature and there have been limited scientific studies performed to explain the actual results which have been experienced by individuals over time. Accordingly, all the serving information that has been developed by the CBD industry is on an anecdotal basis from the feedback of actual users who have reported their own experiences and serving levels. As a result, individuals who decide to take CBD must assume full responsibility for any products they decide to use and at what serving amount. Each human body is a unique biologic system. Only you can decide what has been effective for you and at what amount. The following information should therefore be considered a series of “baseline recommendations” and are shown for educational purposes only.

    There are many factors that should be taken into consideration with hemp-derived CBD servings:

    Body Mass

    • Up to 125 lbs. should consider a 30mg-per-day starting daily serving, larger people would want to use roughly a proportional increased amount


    • Age (faster metabolism in 25 year old vs. a 75 year old).
    • Activity level and general health.
    • Younger or more active people may want to increase frequency of use, perhaps adding a mid-day serving to a morning and night serving schedule.


    • Reportedly, neurological symptoms (e.g., periodic nervousness) often require less mg per day of CBD-hd to be effective: 30-50mg daily
    • Occasional pain seems to require the highest amount, generally between 80-300mg daily. Individuals who suffer from more severe levels of this pain have indicated that they sometimes did not experience significant
      relief until reaching +100mg daily

    True or false—the more mg of CBD you take, the better the relief?

    • Generally true: described as relief from occasional pain that users expanded upon as their serving amount increased (once you experience some relief at an identified # of mg/day, keep increasing the total daily amount of mg/day until you find maximum effectiveness for your
      (“sweet spot”)
    • And false: few people may experience less desirable effects including an energy boost/euphoria at higher amounts.

    Full Spectrum vs. Broad Spectrum vs. Isolated CBD

    Full-Spectrum CBD Contains trace amounts of THC Delta-9 and does not exceed the legal threshold of 0.3% THC (proper manufacturing and lab testing necessary to ensure that THC levels are within federal guidelines
    — Superior efficacy when compared to other CBD products
    — Longer lasting effects (up to 12 hours) and fat soluble
    — From the whole plant: contains more than just CBD including other minor cannabinoids, terpenes, and flavonoids.

    Broad-Spectrum CBD — Falls between full-spectrum CBD and isolated CBD
    — Like full-spectrum CBD, the other compounds found within the plant are preserved in the extract
    — Contains ZERO THC and is completely non-detectable
    — Considered the “next best thing” to full-spectrum CBD
    — Broad spectrum CBD is used by people in sensitive job roles that are subjected to THC drug testing (ie: Police Officers, Pilots, CDL Operators).

    Isolated (pure CBD) — Contains ZERO THC, but only offers a single cannabinoid with no “entourage effect”
    — Has potential to sometimes work well initially, but usually doesn’t offer noticeable effects after 2-4 weeks, if at all
    — Shorter acting and water soluble—flushes out of the body faster
    — Cheap to manufacture and often used to trick uneducated consumers in to purchasing an inferior product
    — Can be good affective in skin care and topical applications

    Efficacy of CBD on the body (by route of entry)*

    • 100% efficacy: Injected into vein (fastest acting, but dangerous)
    • +-80 efficacy: Smoking (unknown long term health effects, potentially bad)
    • +-60% efficacy: Sublingual absorption (oil under the tongue is the #1 recommended administration route for CBD)
      — 20 minutes to theoretically have the ability to affect every cell in the human body
    • 10-20% efficacy: Oral consumption (eating)
      — Longer lasting effects, but poor efficacy—digested and broken down by stomach enzymes, then hepatic system (liver) scrubs before entering bloodstream

    In general, because the CBD supplement industry is still relatively new, there is a variety of opinions on exactly the right serving amounts for individuals based on age, weight, condition, etc. 

    Fortunately, CBD has been widely shown to be well-tolerated by most people. Wellphora offers a range of potencies** to make it easier for you to get just the right amount for your particular needs.

    * Efficacy levels shown are reflective of the delivery, or entry system only, and are not in any way associated with the amount of CBD contained in a product.
    ** Contact our customer service department by email: or call 480-369-3199 for more dosing instructions and to find out which products best fit your individual needs.

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